› 6c4y

X-ray diffraction
2.5Å resolution

Cross-alpha Amyloid-like Structure alphaAmG

Released:
DOI: 10.2210/pdb6c4y/pdb
PDB entry 6c4y coloured by chain, front view.
PDB entry 6c4y coloured by chain, side view.
PDB entry 6c4y coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Designed peptides that assemble into cross-α amyloid-like structures.
Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF
Nat Chem Biol 14 870-875 (2018)
PMID: 30061717

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166493 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cross-alpha Amyloid-like Structure alphaAmG Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Length: 27 amino acids
Theoretical weight: 2.92 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P4322
Unit cell:
a: 125.241Å b: 125.241Å c: 119.026Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.237 0.259
Expression system: Not provided

Quick links

Citations

3 review citations

Recent advances in de novo protein design: Principles, methods, and applications.
Pan et al. (2021)
2 more

1 mention without citation

Protein Design: From the Aspect of Water Solubility and Stability.
Qing et al. (2022)