› 6c52

X-ray diffraction
1.6Å resolution

Cross-alpha Amyloid-like Structure alphaTet

Released:
DOI: 10.2210/pdb6c52/pdb
PDB entry 6c52 coloured by chain, front view.
PDB entry 6c52 coloured by chain, side view.
PDB entry 6c52 coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Designed peptides that assemble into cross-α amyloid-like structures.
Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF
Nat Chem Biol 14 870-875 (2018)
PMID: 30061717

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166497 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cross-alpha Amyloid-like Structure alphaTet Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 27 amino acids
Theoretical weight: 3.12 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21212
Unit cell:
a: 47.45Å b: 75.57Å c: 27.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.222
Expression system: Not provided

Quick links

Citations

3 review citations

Recent advances in de novo protein design: Principles, methods, and applications.
Pan et al. (2021)
2 more

2 mentions without citation

Protein Design: From the Aspect of Water Solubility and Stability.
Qing et al. (2022)
1 more