› 6c9l

X-ray diffraction
2.3Å resolution

MEF2B Apo Protein Structure

Released:
DOI: 10.2210/pdb6c9l/pdb
PDB entry 6c9l coloured by chain, front view.
PDB entry 6c9l coloured by chain, side view.
PDB entry 6c9l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of Apo MEF2B Reveals New Insights in DNA Binding and Cofactor Interaction.
Lei X, Shi H, Kou Y, Rajashekar N, Wu F, Sen C, Xu J, Chen L
Biochemistry 57 4047-4051 (2018)
PMID: 29944822

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myocyte-specific enhancer factor 2B Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 93 amino acids
Theoretical weight: 11.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02080 (Residues: 1-93; Coverage: 26%)
Gene names: MEF2B, XMEF2
Sequence domains: SRF-type transcription factor (DNA-binding and dimerisation domain)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P21
Unit cell:
a: 34.78Å b: 178.49Å c: 43.41Å
α: 90° β: 96.36° γ: 90°
R-values:
R R work R free
0.216 0.215 0.235
Expression system: Escherichia coli

Quick links

Citations

1 review citation

MEF-2 isoforms' (A-D) roles in development and tumorigenesis.
Madugula et al. (2019)
1 other article

1 mention without citation

Structural Basis for Plant MADS Transcription Factor Oligomerization.
Lai et al. (2019)