› 6cmj

X-ray diffraction
2.4Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188735 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 321 amino acids
Theoretical weight: 36.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96RR4 (Residues: 149-465; Coverage: 51%)
Gene names: CAMKK2, CAMKKB, KIAA0787
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand F6J 2 x F6J
Ligand FMT 6 x FMT
Ligand EDO 3 x EDO
2 modified residues:
Ligand SEP 4 x SEP
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P3121
Unit cell:
a: 89.841Å b: 89.841Å c: 181.385Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.182 0.219
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Molecular Mechanisms Underlying Ca2+/Calmodulin-Dependent Protein Kinase Kinase Signal Transduction.
Tokumitsu et al. (2022)
1 more

4 mentions without citation

BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes.
Kim et al. (2020)
3 more