› 6cmx

Electron Microscopy
3.1Å resolution

Human Teneurin 2 extra-cellular region

Released:
DOI: 10.2210/pdb6cmx/pdb
PDB entry 6cmx coloured by chain, front view.
PDB entry 6cmx coloured by chain, side view.
PDB entry 6cmx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
Li J, Shalev-Benami M, Sando R, Jiang X, Kibrom A, Wang J, Leon K, Katanski C, Nazarko O, Lu YC, Südhof TC, Skiniotis G, Araç D
Cell 173 735-748.e15 (2018)
PMID: 29677516
Related structures: EMD-7526

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192598 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Ten-2, soluble form Chain: A
Molecule details ›
Chain: A
Length: 1999 amino acids
Theoretical weight: 224.01 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NT68 (Residues: 846-2774; Coverage: 69%)
Gene names: KIAA1127, ODZ2, TENM2, TNM2
Sequence domains: GHH signature containing HNH/Endo VII superfamily nuclease toxin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 9 x NAG
Ligand MAN 3 x MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-7526
Expression system: Trichoplusia ni

Quick links

Citations

23 review citations

Revisiting and refining roles of neural guidance cues in circuit assembly.
Dorskind et al. (2021)
22 more

8 mentions without citation

Towards an Understanding of Synapse Formation.
Südhof TC. (2018)
7 more