› 6coz

Electron Microscopy
3.36Å resolution

Human CLC-1 chloride ion channel, C-terminal cytosolic domain

Released:
DOI: 10.2210/pdb6coz/pdb
PDB entry 6coz coloured by chain, front view.
PDB entry 6coz coloured by chain, side view.
PDB entry 6coz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the CLC-1 chloride channel from Homo sapiens.
Park E, MacKinnon R
Elife 7 (2018)
PMID: 29809153
Related structures: EMD-7545

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152936 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride channel protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 988 amino acids
Theoretical weight: 108.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P35523 (Residues: 1-988; Coverage: 100%)
Gene names: CLC1, CLCN1
Sequence domains: Voltage gated chloride channel

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.36Å
Relevant EMDB volumes: EMD-7545
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Frontiers in Cryo Electron Microscopy of Complex Macromolecular Assemblies.
Ognjenović et al. (2019)
10 more

3 mentions without citation

The Role of Chloride Channels in Plant Responses to NaCl.
Liu et al. (2023)
2 more