› 6cpk

Solution NMR

Solution structure of SH3 domain from Shank3

Released:
DOI: 10.2210/pdb6cpk/pdb
PDB entry 6cpk coloured by chain, ensemble of 25 models, front view.
PDB entry 6cpk coloured by chain, ensemble of 25 models, side view.
PDB entry 6cpk coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels.
Ishida H, Skorobogatov A, Yamniuk AP, Vogel HJ
FEBS Lett 592 2786-2797 (2018)
PMID: 30058071

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189825 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH3 and multiple ankyrin repeat domains protein 3 Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 6.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BYB0 (Residues: 471-530; Coverage: 4%)
Gene names: KIAA1650, PROSAP2, PSAP2, SHANK3
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 40%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Dysregulated Signaling at Postsynaptic Density: A Systematic Review and Translational Appraisal for the Pathophysiology, Clinics, and Antipsychotics' Treatment of Schizophrenia.
de Bartolomeis et al. (2023)
1 more

1 mention without citation

Quantum refinement with multiple conformations: application to the P-cluster in nitrogenase.
Cao et al. (2020)