› 6cs9

X-ray diffraction
1.85Å resolution

Crystal structure of human beta-defensin 2 in complex with PIP2

Released:
DOI: 10.2210/pdb6cs9/pdb
PDB entry 6cs9 coloured by chain, front view.
PDB entry 6cs9 coloured by chain, side view.
PDB entry 6cs9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human β-defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization.
Järvå M, Phan TK, Lay FT, Caria S, Kvansakul M, Hulett MD
Sci Adv 4 eaat0979 (2018)
PMID: 30050988

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127396 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Defensin beta 4A Chains: A, B
Molecule details ›
Chains: A, B
Length: 41 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: O15263 (Residues: 24-64; Coverage: 100%)
Gene names: DEFB102, DEFB2, DEFB4, DEFB4A, DEFB4B
Sequence domains: Beta defensin
Structure domains: Antimicrobial Peptide, Beta-defensin 2; Chain A

Ligands and Environments

1 bound ligand:
Ligand PIO 2 x PIO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 32.871Å b: 25.538Å c: 40.17Å
α: 90° β: 98.64° γ: 90°
R-values:
R R work R free
0.196 0.195 0.227
Expression system: Komagataella pastoris

Quick links

Citations

7 review citations

Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin.
Galocha et al. (2019)
6 more

3 mentions without citation

Defensin-lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics.
Hein et al. (2022)
2 more