› 6csu

X-ray diffraction
2.5Å resolution

The structure of the Cep63-Cep152 heterotetrameric complex

Released:
DOI: 10.2210/pdb6csu/pdb
PDB entry 6csu coloured by chain, front view.
PDB entry 6csu coloured by chain, side view.
PDB entry 6csu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular architecture of a cylindrical self-assembly at human centrosomes.
Kim TS, Zhang L, Il Ahn J, Meng L, Chen Y, Lee E, Bang JK, Lim JM, Ghirlando R, Fan L, Wang YX, Kim BY, Park JE, Lee KS
Nat Commun 10 1151 (2019)
PMID: 30858376

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131808 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Centrosomal protein of 152 kDa Chains: B, D
Molecule details ›
Chains: B, D
Length: 54 amino acids
Theoretical weight: 6.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94986 (Residues: 1261-1313; Coverage: 3%)
Gene names: CEP152, KIAA0912
Centrosomal protein of 63 kDa Chains: A, C
Molecule details ›
Chains: A, C
Length: 44 amino acids
Theoretical weight: 5.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96MT8 (Residues: 664-703; Coverage: 6%)
Gene name: CEP63

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 28.066Å b: 41.523Å c: 205.619Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.254 0.25 0.285
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The Centrosome and the Primary Cilium: The Yin and Yang of a Hybrid Organelle.
Joukov et al. (2019)
5 more

2 mentions without citation

Molecular architecture of a cylindrical self-assembly at human centrosomes.
Kim et al. (2019)
1 more