› 6d02

X-ray diffraction
2.5Å resolution

Cross-alpha Amyloid-like Structure alphaAmL, 2nd form

Released:
DOI: 10.2210/pdb6d02/pdb
PDB entry 6d02 coloured by chain, front view.
PDB entry 6d02 coloured by chain, side view.
PDB entry 6d02 coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Designed peptides that assemble into cross-α amyloid-like structures.
Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF
Nat Chem Biol 14 870-875 (2018)
PMID: 30061717

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo 32-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166568 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
alpha-Amyloid peptide alphaAmL Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f
Length: 27 amino acids
Theoretical weight: 2.97 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand MPD 1 x MPD
Ligand PO4 3 x PO4
Ligand CO3 1 x CO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21212
Unit cell:
a: 107.546Å b: 107.777Å c: 99.374Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.232 0.277
Expression system: Not provided

Quick links

Citations

5 review citations

De novo protein design, a retrospective.
Korendovych et al. (2020)
4 more

1 mention without citation

Designed peptides that assemble into cross-α amyloid-like structures.
Zhang et al. (2018)