› 6d0l

X-ray diffraction
1.97Å resolution

Structure of human TIRR

Released:
DOI: 10.2210/pdb6d0l/pdb
PDB entry 6d0l coloured by chain, front view.
PDB entry 6d0l coloured by chain, side view.
PDB entry 6d0l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.
Botuyan MV, Cui G, Drané P, Oliveira C, Detappe A, Brault ME, Parnandi N, Chaubey S, Thompson JR, Bragantini B, Zhao D, Chapman JR, Chowdhury D, Mer G
Nat Struct Mol Biol 25 591-600 (2018)
PMID: 29967538

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189688 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tudor-interacting repair regulator protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 207 amino acids
Theoretical weight: 23.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BRJ7 (Residues: 6-211; Coverage: 98%)
Gene names: NUDT16L1, SDOS, TIRR
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P1
Unit cell:
a: 41.89Å b: 46.36Å c: 48.8Å
α: 92.31° β: 108.07° γ: 105.75°
R-values:
R R work R free
0.176 0.174 0.209
Expression system: Escherichia coli

Quick links

Citations

7 review citations

53BP1: a DSB escort.
Mirman et al. (2020)
6 more

2 mentions without citation

Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.
Botuyan et al. (2018)
1 more