› 6d3n

X-ray diffraction
2.7Å resolution

Crystal structure of h4-1BB ligand

Released:
DOI: 10.2210/pdb6d3n/pdb
PDB entry 6d3n coloured by chain, front view.
PDB entry 6d3n coloured by chain, side view.
PDB entry 6d3n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier.
Bitra A, Doukov T, Croft M, Zajonc DM
J Biol Chem 293 9958-9969 (2018)
PMID: 29720398

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154371 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 9 Chain: A
Molecule details ›
Chain: A
Length: 171 amino acids
Theoretical weight: 18.32 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P41273 (Residues: 80-244; Coverage: 65%)
Gene name: TNFSF9
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: R32
Unit cell:
a: 73.167Å b: 73.167Å c: 162.814Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.208 0.252
Expression system: Insect cell expression vector pTIE1

Quick links

Citations

7 review citations

A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains.
Cappell et al. (2021)
6 more

4 mentions without citation

Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier.
Bitra et al. (2018)
3 more