› 6d42

X-ray diffraction
1.75Å resolution

Crystal structure of the KCa3.1 C-terminal four-helix bundle (with copper)

Released:
DOI: 10.2210/pdb6d42/pdb
PDB entry 6d42 coloured by chain, front view.
PDB entry 6d42 coloured by chain, side view.
PDB entry 6d42 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1.
Ji T, Corbalán-García S, Hubbard SR
PLoS One 13 e0199942 (2018)
PMID: 29953543

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127534 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Intermediate conductance calcium-activated potassium channel protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 42 amino acids
Theoretical weight: 4.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15554 (Residues: 376-415; Coverage: 9%)
Gene names: IK1, IKCA1, KCA4, KCNN4, SK4

Ligands and Environments

1 bound ligand:
Ligand CU 2 x CU
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P4212
Unit cell:
a: 37.59Å b: 37.59Å c: 116.946Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.259 0.252 0.323
Expression system: Escherichia coli

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Citations

1 review citation

Modulation of Adaptive Immunity and Viral Infections by Ion Channels.
Bohmwald et al. (2021)
1 other article

3 mentions without citation

Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1.
Ji et al. (2018)
2 more