› 6dca

X-ray diffraction
2.6Å resolution

Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope.

Released:
DOI: 10.2210/pdb6dca/pdb
PDB entry 6dca coloured by chain, front view.
PDB entry 6dca coloured by chain, side view.
PDB entry 6dca coloured by chain, top view.
Source organisms:
Primary publication:
Structural characterization of monoclonal antibodies targeting C-terminal Ser404 region of phosphorylated tau protein.
Chukwu JE, Congdon EE, Sigurdsson EM, Kong XP
MAbs 11 477-488 (2019)
PMID: 30794086

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210478 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab light chain Chains: L, M, N, O
Molecule details ›
Chains: L, M, N, O
Length: 218 amino acids
Theoretical weight: 23.98 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Fab heavy chain Chains: H, I, J, K
Molecule details ›
Chains: H, I, J, K
Length: 221 amino acids
Theoretical weight: 23.84 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Microtubule-associated protein tau Chains: P, Q, R, S
Molecule details ›
Chains: P, Q, R, S
Length: 31 amino acids
Theoretical weight: 3.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 696-725; Coverage: 4%)
Gene names: MAPT, MAPTL, MTBT1, TAU

Ligands and Environments

1 bound ligand:
Ligand PO4 4 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-BM-B
Spacegroup: P1
Unit cell:
a: 54.01Å b: 59.704Å c: 143.846Å
α: 89.43° β: 92.69° γ: 97.35°
R-values:
R R work R free
0.191 0.189 0.259
Expression system: Not provided

Quick links

Citations

3 review citations

Treatment of Alzheimer's Disease and Blood-Brain Barrier Drug Delivery.
Pardridge WM. (2020)
2 more

2 mentions without citation

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status.
Pinzi et al. (2023)
1 more