› 6dfd

X-ray diffraction
1.9Å resolution

Crystal structure of CNNM3 cyclic nucleotide-binding homology domain

Released:
DOI: 10.2210/pdb6dfd/pdb
PDB entry 6dfd coloured by chain, front view.
PDB entry 6dfd coloured by chain, side view.
PDB entry 6dfd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The cyclic nucleotide-binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity.
Chen YS, Kozlov G, Fakih R, Funato Y, Miki H, Gehring K
J Biol Chem 293 19998-20007 (2018)
PMID: 30341174

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185503 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metal transporter CNNM3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 260 amino acids
Theoretical weight: 29.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8NE01 (Residues: 453-707; Coverage: 36%)
Gene names: ACDP3, CNNM3

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 14 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P42212
Unit cell:
a: 101.267Å b: 101.267Å c: 77.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.219 0.239
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Magnesium, Little Known But Possibly Relevant: A Link between NASH and Related Comorbidities.
Simón et al. (2021)
2 more

2 mentions without citation

Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators.
Giménez-Mascarell et al. (2019)
1 more