6djp

Electron Microscopy
4.8Å resolution

Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-209293 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (9 distinct):
Integrin alpha-V Chain: A
Molecule details ›
Chain: A
Length: 965 amino acids
Theoretical weight: 106.76 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P06756 (Residues: 31-995; Coverage: 95%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Integrin beta-8 Chain: B
Molecule details ›
Chain: B
Length: 639 amino acids
Theoretical weight: 70.84 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P26012 (Residues: 43-681; Coverage: 88%)
Gene name: ITGB8
Sequence domains:
8B8 heavy chain Fab Chain: C
Molecule details ›
Chain: C
Length: 213 amino acids
Theoretical weight: 23.31 KDa
Source organism: Mus musculus
Expression system: Mus musculus
8B8 light chain Fab Chain: D
Molecule details ›
Chain: D
Length: 213 amino acids
Theoretical weight: 23.24 KDa
Source organism: Mus musculus
Expression system: Mus musculus
68 heavy chain Fab Chain: E
Molecule details ›
Chain: E
Length: 212 amino acids
Theoretical weight: 22.68 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
68 light chain Fab Chain: F
Molecule details ›
Chain: F
Length: 214 amino acids
Theoretical weight: 23.42 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.8Å
Relevant EMDB volumes: EMD-7939
Expression systems:
  • Cricetulus griseus
  • Mus musculus