› 6dk5

X-ray diffraction
1.85Å resolution

The X-ray crystal structure of human endothelin-1, a polypeptide hormone regulator of blood pressure

Released:
DOI: 10.2210/pdb6dk5/pdb
PDB entry 6dk5 coloured by chain, front view.
PDB entry 6dk5 coloured by chain, side view.
PDB entry 6dk5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The X-ray crystal structure of human endothelin 1, a polypeptide hormone regulator of blood pressure.
McPherson A, Larson SB
Acta Crystallogr F Struct Biol Commun 75 47-53 (2019)
PMID: 30605125

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138621 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endothelin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 21 amino acids
Theoretical weight: 2.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05305 (Residues: 53-73; Coverage: 11%)
Gene name: EDN1
Sequence domains: Endothelin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P61
Unit cell:
a: 27.328Å b: 27.328Å c: 79.538Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.204 0.284

Quick links

Citations

2 review citations

Antibodies against Angiotensin II Type 1 and Endothelin A Receptors: Relevance and pathogenicity.
Philogene et al. (2019)
1 more

3 mentions without citation

The X-ray crystal structure of human endothelin 1, a polypeptide hormone regulator of blood pressure.
McPherson et al. (2019)
2 more