› 6dkj

X-ray diffraction
1.95Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-143683 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin gamma-1 heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 223 amino acids
Theoretical weight: 23.81 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P0DOX5 (Residues: 1-107, 108-222; Coverage: 49%)
Sequence domains:
Ig-like domain-containing protein Chains: B, L
Molecule details ›
Chains: B, L
Length: 214 amino acids
Theoretical weight: 23.21 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: V9HW34 (Residues: 21-235; Coverage: 100%)
Gene name: HEL-213
Sequence domains:
Structure domains: Immunoglobulins
Gastric inhibitory polypeptide receptor Chains: C, D
Molecule details ›
Chains: C, D
Length: 117 amino acids
Theoretical weight: 13.45 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P48546 (Residues: 22-138; Coverage: 26%)
Gene name: GIPR
Sequence domains: Hormone receptor domain

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 55.907Å b: 63.649Å c: 159.099Å
α: 90° β: 92.56° γ: 90°
R-values:
R R work R free
0.2 0.199 0.238
Expression system: Cricetulus griseus

Quick links

Citations

35 review citations

Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease.
Baggio et al. (2021)
34 more

2 mentions without citation

Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor.
Min et al. (2020)
1 more