› 6dlo

X-ray diffraction
2.7Å resolution

Crystal structure of LRRK2 WD40 domain dimer

Released:
DOI: 10.2210/pdb6dlo/pdb
PDB entry 6dlo coloured by chain, front view.
PDB entry 6dlo coloured by chain, side view.
PDB entry 6dlo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the WD40 domain dimer of LRRK2.
Zhang P, Fan Y, Ru H, Wang L, Magupalli VG, Taylor SS, Alessi DR, Wu H
Proc Natl Acad Sci U S A 116 1579-1584 (2019)
PMID: 30635421

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177795 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leucine-rich repeat serine/threonine-protein kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 389 amino acids
Theoretical weight: 43.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q5S007 (Residues: 2142-2527; Coverage: 15%)
Gene names: LRRK2, PARK8

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 79.293Å b: 103.59Å c: 112.664Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.234 0.275
Expression system: Spodoptera frugiperda

Quick links

Citations

13 review citations

LRRK2 links genetic and sporadic Parkinson's disease.
Kluss et al. (2019)
12 more

6 mentions without citation

An Update on the Interplay between LRRK2, Rab GTPases and Parkinson's Disease.
Komori et al. (2023)
5 more