› 6dr6

X-ray diffraction
2.61Å resolution

X-ray crystallographic structure of a covalent trimer derived from A-beta 17_36 containing the F20Cha point mutation

Released:
DOI: 10.2210/pdb6dr6/pdb
Model geometry
Fit model/data
PDB entry 6dr6 coloured by chain, front view.
PDB entry 6dr6 coloured by chain, side view.
PDB entry 6dr6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from Aβ.
Salveson PJ, Haerianardakani S, Thuy-Boun A, Yoo S, Kreutzer AG, Demeler B, Nowick JS
J Am Chem Soc 140 11745-11754 (2018)
PMID: 30125493

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166624 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ORT-CYS-VAL-PHE-XXX-CYS-GLU-ASP-ORT-ALA-ILE-ILE-GLY-LEU-ORA-VAL Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 16 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
2 modified residues:
Ligand ORN 12 x ORN
Ligand H7V 4 x H7V

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P6322
Unit cell:
a: 58.058Å b: 58.058Å c: 95.609Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.242 0.277
Expression system: Not provided

Quick links

Citations

2 review citations

Exploring amyloid oligomers with peptide model systems.
Samdin et al. (2021)
1 more

2 mentions without citation

Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from Aβ.
Salveson et al. (2018)
1 more