6dzl

Electron Microscopy
4.14Å resolution

Ebola virus Makona variant GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-211537 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (6 distinct):
GP1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 321 amino acids
Theoretical weight: 35.52 KDa
Source organism: Ebola virus - Zaire (1995)
Expression system: Homo sapiens
UniProt:
  • Canonical: P87666 (Residues: 32-311; Coverage: 43%)
Gene name: GP
Sequence domains: Filovirus glycoprotein
Shed GP Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 166 amino acids
Theoretical weight: 18.33 KDa
Source organism: Ebola virus - Zaire (1995)
Expression system: Homo sapiens
UniProt:
  • Canonical: P87666 (Residues: 504-629; Coverage: 20%)
Gene name: GP
Fv domain of ADI-15878 Fab light chain Chains: J, K, L
Molecule details ›
Chains: J, K, L
Length: 106 amino acids
Theoretical weight: 11.33 KDa
Source organism: Homo sapiens
Expression system: Nicotiana benthamiana
Fv domain of ADI-15878 Fab heavy chain Chains: G, H, I
Molecule details ›
Chains: G, H, I
Length: 121 amino acids
Theoretical weight: 13.17 KDa
Source organism: Homo sapiens
Expression system: Nicotiana benthamiana

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.14Å
Relevant EMDB volumes: EMD-8935
Expression systems:
  • Homo sapiens
  • Nicotiana benthamiana