6e2j

X-ray diffraction
2.39Å resolution

Crystal structure of the heterocomplex between human keratin 1 coil 1B containing S233L mutation and wild-type human keratin 10 coil 1B

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
hetero octamer
PDBe Complex ID:
PDB-CPX-137543 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Keratin, type II cytoskeletal 1 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04264 (Residues: 226-331; Coverage: 17%)
Gene names: KRT1, KRTA
Sequence domains: Intermediate filament protein
Keratin, type I cytoskeletal 10 Chain: B
Molecule details ›
Chain: B
Length: 104 amino acids
Theoretical weight: 12.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13645 (Residues: 195-296; Coverage: 18%)
Gene names: KPP, KRT10
Sequence domains: Intermediate filament protein

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6422
Unit cell:
a: 93.296Å b: 93.296Å c: 124.742Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.272 0.271 0.294
Expression system: Escherichia coli