Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Leptin receptor and Tyrosine-protein kinase JAK2 (preferred)
PDBe Complex ID:
PDB-CPX-130065 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase JAK2
Molecule details ›
Chains: A, B
Length: 484 amino acids
Theoretical weight: 55.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 484 amino acids
Theoretical weight: 55.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
O60674 (Residues: 36-514; Coverage: 42%)
Sequence domains:
Leptin receptor
Molecule details ›
Chains: C, D
Length: 75 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Length: 75 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P48357 (Residues: 863-933; Coverage: 6%)
