› 6e7p

Electron Microscopy
3.5Å resolution

cryo-EM structure of human TRPML1 with PI35P2

Released:
DOI: 10.2210/pdb6e7p/pdb
PDB entry 6e7p coloured by chain, front view.
PDB entry 6e7p coloured by chain, side view.
PDB entry 6e7p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Fine M, Schmiege P, Li X
Nat Commun 9 4192 (2018)
PMID: 30305615
Related structures: EMD-9000

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190453 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucolipin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 580 amino acids
Theoretical weight: 65.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9GZU1 (Residues: 1-580; Coverage: 100%)
Gene names: MCOLN1, ML4, MSTP080, TRPML1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand HZ7 4 x HZ7
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-9000
Expression system: Homo sapiens

Quick links

Citations

14 review citations

Lysosomal Ca2+ Homeostasis and Signaling in Health and Disease.
Lloyd-Evans et al. (2020)
13 more

2 mentions without citation

Interfacial Binding Sites for Cholesterol on TRP Ion Channels.
Lee AG. (2019)
1 more