Function and Biology Details
Reaction catalysed:
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Insulin-degrading enzyme and Glucagon (preferred)
PDBe Complex ID:
PDB-CPX-134155 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin-degrading enzyme
Molecule details ›
Chains: A, B
Length: 978 amino acids
Theoretical weight: 113.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 978 amino acids
Theoretical weight: 113.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P14735 (Residues: 42-1019; Coverage: 96%)
Sequence domains:
- Insulinase (Peptidase family M16)
- Peptidase M16 inactive domain
- Middle or third domain of peptidase_M16
Glucagon
Molecule details ›
Chains: C, D
Length: 29 amino acids
Theoretical weight: 3.49 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains: Peptide hormone
Length: 29 amino acids
Theoretical weight: 3.49 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical: P01275 (Residues: 53-81; Coverage: 18%)
Sequence domains: Peptide hormone
