› 6ei3

X-ray diffraction
2.1Å resolution

Crystal structure of auto inhibited POT family peptide transporter

Released:
DOI: 10.2210/pdb6ei3/pdb
PDB entry 6ei3 coloured by chain, front view.
PDB entry 6ei3 coloured by chain, side view.
PDB entry 6ei3 coloured by chain, top view.
Source organism: Xanthomonas campestris
Primary publication:
Proton movement and coupling in the POT family of peptide transporters.
Parker JL, Li C, Brinth A, Wang Z, Vogeley L, Solcan N, Ledderboge-Vucinic G, Swanson JMJ, Caffrey M, Voth GA, Newstead S
Proc Natl Acad Sci U S A 114 13182-13187 (2017)
PMID: 29180426

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185732 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oligopeptide transporter Chain: A
Molecule details ›
Chain: A
Length: 514 amino acids
Theoretical weight: 56.63 KDa
Source organism: Xanthomonas campestris
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8PAS2 (Residues: 115-620; Coverage: 82%)
Gene names: XCC1406, ygdR
Sequence domains: POT family
Structure domains: MFS general substrate transporter like domains

Ligands and Environments

1 bound ligand:
Ligand 78M 17 x 78M
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2
Unit cell:
a: 138.06Å b: 65.23Å c: 70.34Å
α: 90° β: 96.84° γ: 90°
R-values:
R R work R free
0.181 0.179 0.214
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Clinical trials in autism spectrum disorder: evidence, challenges and future directions.
Anagnostou E. (2018)
5 more

5 mentions without citation

Recent advances in understanding prodrug transport through the SLC15 family of proton-coupled transporters.
Minhas et al. (2020)
4 more