› 6eit

Electron Microscopy
3.9Å resolution

Coxsackievirus A24v in complex with the D1-D2 fragment of ICAM-1

Released:
DOI: 10.2210/pdb6eit/pdb
PDB entry 6eit coloured by chain, front view.
PDB entry 6eit coloured by chain, side view.
PDB entry 6eit coloured by chain, top view.
Source organisms:
Primary publication:
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus.
Baggen J, Hurdiss DL, Zocher G, Mistry N, Roberts RW, Slager JJ, Guo H, van Vliet ALW, Wahedi M, Benschop K, Duizer E, de Haan CAM, de Vries E, Casasnovas JM, de Groot RJ, Arnberg N, Stehle T, Ranson NA, Thibaut HJ, van Kuppeveld FJM
Proc Natl Acad Sci U S A 115 397-402 (2018)
PMID: 29284752
Related structures: EMD-3880

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 240-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138638 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
VP1 Chain: 1
Molecule details ›
Chain: 1
Length: 305 amino acids
Theoretical weight: 34.38 KDa
Source organism: Coxsackievirus A24
UniProt:
  • Canonical: V9VEF3 (Residues: 581-885; Coverage: 14%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls
VP2 Chain: 2
Molecule details ›
Chain: 2
Length: 271 amino acids
Theoretical weight: 29.82 KDa
Source organism: Coxsackievirus A24
UniProt:
  • Canonical: V9VEF3 (Residues: 70-340; Coverage: 12%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls
VP3 Chain: 3
Molecule details ›
Chain: 3
Length: 240 amino acids
Theoretical weight: 26.64 KDa
Source organism: Coxsackievirus A24
UniProt:
  • Canonical: V9VEF3 (Residues: 341-580; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls
Intercellular adhesion molecule 1 Chain: 4
Molecule details ›
Chain: 4
Length: 85 amino acids
Theoretical weight: 9.3 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05362 (Residues: 28-112; Coverage: 17%)
Gene name: ICAM1
Sequence domains: Intercellular adhesion molecule (ICAM), N-terminal domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-3880
Expression system: Cricetulus griseus

Quick links

Citations

5 review citations

The life cycle of non-polio enteroviruses and how to target it.
Baggen et al. (2018)
4 more

3 mentions without citation

Virus-Receptor Interactions: Structural Insights For Oncolytic Virus Development.
Jayawardena et al. (2019)
2 more