› 6eiz

X-ray diffraction
1.85Å resolution

A de novo designed hexameric coiled coil CC-Hex2 with farnesol bound in the channel.

Released:
DOI: 10.2210/pdb6eiz/pdb
PDB entry 6eiz coloured by chain, front view.
PDB entry 6eiz coloured by chain, side view.
PDB entry 6eiz coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
De Novo-Designed α-Helical Barrels as Receptors for Small Molecules.
Thomas F, Dawson WM, Lang EJM, Burton AJ, Bartlett GJ, Rhys GG, Mulholland AJ, Woolfson DN
ACS Synth Biol 7 1808-1816 (2018)
PMID: 29944338

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CC-Hex2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 32 amino acids
Theoretical weight: 3.3 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand FOF 1 x FOF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2221
Unit cell:
a: 59.08Å b: 126.23Å c: 58.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.258
Expression system: Not provided

Quick links

Citations

5 review citations

Protein Design: From the Aspect of Water Solubility and Stability.
Qing et al. (2022)
4 more