› 6el8

X-ray diffraction
1.61Å resolution

Crystal structure of the Forkhead domain of human FOXN1 in complex with DNA

Released:
DOI: 10.2210/pdb6el8/pdb
PDB entry 6el8 coloured by chain, front view.
PDB entry 6el8 coloured by chain, side view.
PDB entry 6el8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Newman JA, Aitkenhead HA, Pinkas DM, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Gileadi O, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-119844 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Forkhead box protein N1 Chains: A, D
Molecule details ›
Chains: A, D
Length: 99 amino acids
Theoretical weight: 11.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15353 (Residues: 270-366; Coverage: 15%)
Gene names: FOXN1, RONU, WHN
Sequence domains: Forkhead domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
DNA (5'-D(*GP*GP*TP*GP*GP*CP*GP*TP*CP*TP*TP*CP*A)-3') Chains: B, E
Molecule details ›
Chains: B, E
Length: 13 nucleotides
Theoretical weight: 4 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA (5'-D(*TP*GP*AP*AP*GP*AP*CP*GP*CP*CP*AP*CP*C)-3') Chains: C, F
Molecule details ›
Chains: C, F
Length: 13 nucleotides
Theoretical weight: 3.95 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P1
Unit cell:
a: 38.848Å b: 43.284Å c: 58.317Å
α: 90.05° β: 95.67° γ: 93.77°
R-values:
R R work R free
0.196 0.194 0.239
Expression systems:
  • Escherichia coli
  • Not provided

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