› 6eos

X-ray diffraction
3.1Å resolution

DPP8 - Apo, space group 19

Released:
DOI: 10.2210/pdb6eos/pdb
PDB entry 6eos coloured by chain, front view.
PDB entry 6eos coloured by chain, side view.
PDB entry 6eos coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Ross B, Krapp S, Augustin M, Kierfersauer R, Arciniega M, Geiss-Friedlander R, Huber R
Proc Natl Acad Sci U S A 115 E1437-E1445 (2018)
PMID: 29382749

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180439 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 8 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 898 amino acids
Theoretical weight: 103.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6V1X1 (Residues: 1-898; Coverage: 100%)
Gene names: DPP8, DPRP1, MSTP097, MSTP135, MSTP141
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 148.122Å b: 266.778Å c: 268.092Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.247 0.283
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Structures and functions of the inflammasome engine.
Wang et al. (2021)
1 more

2 mentions without citation

Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Ross et al. (2018)
1 more