6es2

X-ray diffraction
2.95Å resolution

Structure of CDX2-DNA(CAA)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-119859 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Homeobox protein CDX-2 Chains: K, L
Molecule details ›
Chains: K, L
Length: 71 amino acids
Theoretical weight: 8.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99626 (Residues: 186-256; Coverage: 23%)
Gene names: CDX2, CDX3
Sequence domains: Homeodomain
DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*TP*TP*GP*CP*CP*TP*CP*C)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 18 nucleotides
Theoretical weight: 5.45 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA (5'-D(P*GP*GP*AP*GP*GP*CP*AP*AP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3') Chains: D, E
Molecule details ›
Chains: D, E
Length: 18 nucleotides
Theoretical weight: 5.58 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Unit cell:
a: 70.248Å b: 46.695Å c: 128.634Å
α: 90° β: 101.4° γ: 90°
R-values:
R R work R free
0.21 0.208 0.244
Expression systems:
  • Escherichia coli
  • Not provided