6es3

X-ray diffraction
2.57Å resolution

Structure of CDX2-DNA(TCG)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-119860 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Homeobox protein CDX-2 Chains: K, M
Molecule details ›
Chains: K, M
Length: 72 amino acids
Theoretical weight: 9.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99626 (Residues: 184-255; Coverage: 23%)
Gene names: CDX2, CDX3
Sequence domains: Homeodomain
DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*CP*GP*AP*CP*CP*TP*CP*C)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 18 nucleotides
Theoretical weight: 5.45 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA (5'-D(P*GP*GP*AP*GP*GP*TP*CP*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3') Chains: E, F
Molecule details ›
Chains: E, F
Length: 18 nucleotides
Theoretical weight: 5.58 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 127.95Å b: 46.49Å c: 68.89Å
α: 90° β: 113.27° γ: 90°
R-values:
R R work R free
0.222 0.216 0.278
Expression systems:
  • Escherichia coli
  • Not provided