6f1u

Electron Microscopy
3.4Å resolution

N terminal region of dynein tail domains in complex with dynactin filament and BICDR-1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tridecamer (preferred)
PDBe Complex ID:
PDB-CPX-105379 (preferred)
Entry contents:
8 distinct polypeptide molecules
Macromolecules (8 distinct):
Alpha-centractin Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 376 amino acids
Theoretical weight: 42.67 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F2Z5G5 (Residues: 1-310; Coverage: 89%)
Gene name: ACTR1A
Sequence domains: Actin
Structure domains:
F-actin-capping protein subunit alpha-1 Chain: K
Molecule details ›
Chain: K
Length: 286 amino acids
Theoretical weight: 33.06 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0PFK5 (Residues: 1-286; Coverage: 100%)
Gene names: CAPZA1, CP alpha1, Capza
Sequence domains: F-actin capping protein alpha subunit
Structure domains:
F-actin-capping protein subunit beta Chain: L
Molecule details ›
Chain: L
Length: 271 amino acids
Theoretical weight: 30.57 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0PFK7 (Residues: 1-271; Coverage: 100%)
Gene name: CAPZB
Sequence domains: F-actin capping protein, beta subunit
Structure domains:
Dynactin subunit 2 Chain: c
Molecule details ›
Chain: c
Length: 50 amino acids
Theoretical weight: 5.58 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A5G2QD80 (Residues: 1-50; Coverage: 12%)
Gene name: DCTN2
Dynactin subunit 2 Chain: d
Molecule details ›
Chain: d
Length: 26 amino acids
Theoretical weight: 2.88 KDa
Source organism: Sus scrofa
UniProt: Gene name: DCTN2
Cytoplasmic dynein 1 heavy chain 1 Chains: f, m, n
Molecule details ›
Chains: f, m, n
Length: 1186 amino acids
Theoretical weight: 136.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14204 (Residues: 1-1186; Coverage: 26%)
Gene names: DHC1, DNCH1, DNCL, DNECL, DYHC, DYNC1H1, KIAA0325
Sequence domains: Dynein heavy chain, N-terminal region 1
Cytoplasmic dynein 1 intermediate chain 2 Chain: h
Molecule details ›
Chain: h
Length: 612 amino acids
Theoretical weight: 68.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13409 (Residues: 1-638; Coverage: 96%)
Gene names: DNCI2, DNCIC2, DYNC1I2
Sequence domains:
BICD family-like cargo adapter 1 Chains: X, x
Molecule details ›
Chains: X, x
Length: 577 amino acids
Theoretical weight: 65.38 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A0JNT9 (Residues: 1-577; Coverage: 100%)
Gene names: Bicdl1, Bicdr1, Ccdc64

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-4169
Expression system: Spodoptera frugiperda