› 6f3v

Solid-state NMR

Backbone structure of bradykinin (BK) peptide bound to human Bradykinin 2 Receptor (B2R) determined by MAS SSNMR

Released:
DOI: 10.2210/pdb6f3v/pdb
PDB entry 6f3v coloured by chain, ensemble of 10 models, front view.
PDB entry 6f3v coloured by chain, ensemble of 10 models, side view.
PDB entry 6f3v coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Joedicke L, Mao J, Kuenze G, Reinhart C, Kalavacherla T, Jonker HRA, Richter C, Schwalbe H, Meiler J, Preu J, Michel H, Glaubitz C
Nat Chem Biol 14 284-290 (2018)
PMID: 29334381

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133899 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bradykinin Chain: A
Molecule details ›
Chain: A
Length: 9 amino acids
Theoretical weight: 1.06 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01042 (Residues: 381-389; Coverage: 1%)
Gene names: BDK, KNG, KNG1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 17%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

10 review citations

GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures.
Shimada et al. (2019)
9 more

2 mentions without citation

Exploiting Knowledge on Structure-Activity Relationships for Designing Peptidomimetics of Endogenous Peptides.
Perez JJ. (2021)
1 more