› 6f51

X-ray diffraction
1.92Å resolution

Crystal structure of glutathione transferase Omega 3S from Trametes versicolor in complex with glutathionyl-phenylacetophenone

Released:
DOI: 10.2210/pdb6f51/pdb
PDB entry 6f51 coloured by chain, front view.
PDB entry 6f51 coloured by chain, side view.
PDB entry 6f51 coloured by chain, top view.
Source organism: Trametes versicolor
Primary publication:
Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor.
Schwartz M, Perrot T, Aubert E, Dumarçay S, Favier F, Gérardin P, Morel-Rouhier M, Mulliert G, Saiag F, Didierjean C, Gelhaye E
Sci Rep 8 8472 (2018)
PMID: 29855494

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-104736 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GST N-terminal domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 246 amino acids
Theoretical weight: 27.53 KDa
Source organism: Trametes versicolor
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A384E145 (Residues: 1-246; Coverage: 100%)
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand CNZ 2 x CNZ
Ligand PEG 2 x PEG
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P212121
Unit cell:
a: 50.45Å b: 104.36Å c: 106.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.217
Expression system: Escherichia coli

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Citations

4 review citations

Modes-of-action of antifungal compounds: Stressors and (target-site-specific) toxins, toxicants, or toxin-stressors.
Noel et al. (2023)
3 more

2 mentions without citation

Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor.
Schwartz et al. (2018)
1 more