6f8g

X-ray diffraction
2.03Å resolution

Co-crystal structure of SPOP MATH domain and hamster Pdx1 fragment

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-129124 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Speckle-type POZ protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 145 amino acids
Theoretical weight: 16.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43791 (Residues: 28-166; Coverage: 37%)
Gene name: SPOP
Sequence domains: MATH domain
Structure domains: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Pancreas/duodenum homeobox protein 1 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 12 amino acids
Theoretical weight: 1.25 KDa
Source organism: Mesocricetus auratus
Expression system: Not provided
UniProt:
  • Canonical: P70118 (Residues: 222-233; Coverage: 4%)
Gene names: IPF1, PDX1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P1
Unit cell:
a: 45.4Å b: 55.17Å c: 58.07Å
α: 89.25° β: 89.89° γ: 86.76°
R-values:
R R work R free
0.188 0.184 0.262
Expression systems:
  • Escherichia coli
  • Not provided