› 6foo

Electron Microscopy
8.2Å resolution

Structure of Ryanodine Receptor 1 in nanodiscs in the presence of calcium and ATP

Released:
DOI: 10.2210/pdb6foo/pdb
PDB entry 6foo coloured by chain, front view.
PDB entry 6foo coloured by chain, side view.
PDB entry 6foo coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Influence of Lipid Mimetics on Gating of Ryanodine Receptor.
Willegems K, Efremov RG
Structure 26 1303-1313.e4 (2018)
PMID: 30078641
Related structures: EMD-4295

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145903 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 5037 amino acids
Theoretical weight: 532.71 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P11716 (Residues: 1-5037; Coverage: 100%)
Gene name: RYR1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 8.2Å
Relevant EMDB volumes: EMD-4295

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Citations

3 review citations

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.
Dulhunty et al. (2018)
2 more