› 6fpr

X-ray diffraction
2.65Å resolution

Co-translational folding intermediate dictates membrane targeting of the signal recognition particle (SRP)- receptor

Released:
DOI: 10.2210/pdb6fpr/pdb
PDB entry 6fpr coloured by chain, front view.
PDB entry 6fpr coloured by chain, side view.
PDB entry 6fpr coloured by chain, top view.
Source organism: Escherichia coli K-12
Primary publication:
Co-translational Folding Intermediate Dictates Membrane Targeting of the Signal Recognition Particle Receptor.
Karniel A, Mrusek D, Steinchen W, Dym O, Bange G, Bibi E
J Mol Biol 430 1607-1620 (2018)
PMID: 29704493

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145174 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Signal recognition particle receptor FtsY Chains: A, B
Molecule details ›
Chains: A, B
Length: 62 amino acids
Theoretical weight: 6.93 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P10121 (Residues: 221-280; Coverage: 12%)
Gene names: JW3429, b3464, ftsY
Sequence domains: SRP54-type protein, helical bundle domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2
Unit cell:
a: 164.573Å b: 35.487Å c: 31.697Å
α: 90° β: 96.48° γ: 90°
R-values:
R R work R free
0.24 0.238 0.277
Expression system: Escherichia coli

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Citations

3 review citations

Cotranslational Folding of Proteins on the Ribosome.
Liutkute et al. (2020)
2 more