› 6fpy

X-ray diffraction
2.34Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148758 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inter-alpha-trypsin inhibitor heavy chain H1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 660 amino acids
Theoretical weight: 73.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P19827 (Residues: 35-672; Coverage: 72%)
Gene names: IGHEP1, ITIH1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand GOL 6 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P42
Unit cell:
a: 158.767Å b: 158.767Å c: 65.371Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.231 0.261
Expression system: Escherichia coli K-12

Quick links

Citations

5 review citations

The Inter-α-Trypsin Inhibitor Family: Versatile Molecules in Biology and Pathology.
Lord et al. (2020)
4 more

6 mentions without citation

Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation.
Briggs et al. (2020)
5 more