› 6fq1

X-ray diffraction
1.31Å resolution

Crystal structure of the RRM12 domain of IMP3

Released:
DOI: 10.2210/pdb6fq1/pdb
PDB entry 6fq1 coloured by chain, front view.
PDB entry 6fq1 coloured by chain, side view.
PDB entry 6fq1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of IMP3 RRM12 recognition of RNA.
Jia M, Gut H, Chao JA
RNA 24 1659-1666 (2018)
PMID: 30135093

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 2 mRNA-binding protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 170 amino acids
Theoretical weight: 19.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00425 (Residues: 1-161; Coverage: 28%)
Gene names: IGF2BP3, IMP3, KOC1, VICKZ3
Sequence domains: RNA recognition motif

Ligands and Environments

1 bound ligand:
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P1
Unit cell:
a: 30.13Å b: 41.58Å c: 72.49Å
α: 92.01° β: 99.91° γ: 108.94°
R-values:
R R work R free
0.142 0.14 0.174
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

IGF2BP3 From Physiology to Cancer: Novel Discoveries, Unsolved Issues, and Future Perspectives.
Mancarella et al. (2019)
3 more

4 mentions without citation

Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng et al. (2021)
3 more