› 6fqr

X-ray diffraction
2.1Å resolution

Crystal structure of IMP3 RRM12 in complex with RNA (CCCC)

Released:
DOI: 10.2210/pdb6fqr/pdb
PDB entry 6fqr coloured by chain, front view.
PDB entry 6fqr coloured by chain, side view.
PDB entry 6fqr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of IMP3 RRM12 recognition of RNA.
Jia M, Gut H, Chao JA
RNA 24 1659-1666 (2018)
PMID: 30135093

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126275 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Insulin-like growth factor 2 mRNA-binding protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 170 amino acids
Theoretical weight: 19.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00425 (Residues: 1-161; Coverage: 28%)
Gene names: IGF2BP3, IMP3, KOC1, VICKZ3
Sequence domains: RNA recognition motif
RNA CCCC Chain: C
Molecule details ›
Chain: C
Length: 4 nucleotides
Theoretical weight: 1.18 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P1
Unit cell:
a: 30.06Å b: 41.19Å c: 72.27Å
α: 92.14° β: 100.4° γ: 108.65°
R-values:
R R work R free
0.17 0.167 0.23
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

4 review citations

IGF2BP3 From Physiology to Cancer: Novel Discoveries, Unsolved Issues, and Future Perspectives.
Mancarella et al. (2019)
3 more

3 mentions without citation

Characterization of epitranscriptome reader proteins experimentally and in silico: Current knowledge and future perspectives beyond the YTH domain.
Miller et al. (2023)
2 more