› 6fr6

X-ray diffraction
2.98Å resolution

HA1.7 Human T-Cell Receptor specific for Influenza virus epitope PKYVKQNTLKLAT presented by Human Leukocyte Antigen HLA-DR0101

Released:
DOI: 10.2210/pdb6fr6/pdb
PDB entry 6fr6 coloured by chain, front view.
PDB entry 6fr6 coloured by chain, side view.
PDB entry 6fr6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.
Holland CJ, MacLachlan BJ, Bianchi V, Hesketh SJ, Morgan R, Vickery O, Bulek AM, Fuller A, Godkin A, Sewell AK, Rizkallah PJ, Wells S, Cole DK
Front Immunol 9 674 (2018)
PMID: 29696015

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214054 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Human T-Cell Receptor Alpha Chain Chain: A
Molecule details ›
Chain: A
Length: 202 amino acids
Theoretical weight: 22.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Human T-cell Receptor Beta Chain Chain: B
Molecule details ›
Chain: B
Length: 241 amino acids
Theoretical weight: 27.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 70Å b: 50.24Å c: 73.17Å
α: 90° β: 93.31° γ: 90°
R-values:
R R work R free
0.205 0.201 0.299
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Structural understanding of T cell receptor triggering.
Xu et al. (2020)
2 more

1 mention without citation

In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.
Holland et al. (2018)