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X-ray diffraction
1.8Å resolution

RORGT (264-518;C455S) IN COMPLEX WITH THE FRAGMENT ("CPD-1") AND RIP140 PEPTIDE AT 1.80A

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-155759 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor ROR-gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P51449 (Residues: 263-518; Coverage: 49%)
Gene names: NR1F3, RORC, RORG, RZRG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor-interacting protein 1 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 20 amino acids
Theoretical weight: 2.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P48552 (Residues: 493-512; Coverage: 2%)
Gene name: NRIP1

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 47.918Å b: 67.874Å c: 82.451Å
α: 90° β: 101.85° γ: 90°
R-values:
R R work R free
0.217 0.215 0.251
Expression system: Escherichia coli BL21