› 6g2t

Electron Microscopy
9Å resolution

human cardiac myosin binding protein C C1 Ig-domain bound to native cardiac thin filament

Released:
DOI: 10.2210/pdb6g2t/pdb
PDB entry 6g2t coloured by chain, front view.
PDB entry 6g2t coloured by chain, side view.
PDB entry 6g2t coloured by chain, top view.
Source organisms:
Primary publication:
N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament.
Risi C, Belknap B, Forgacs-Lonart E, Harris SP, Schröder GF, White HD, Galkin VE
Structure 26 1604-1611.e4 (2018)
PMID: 30270174
Related structures: EMD-4346

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexadecamer (preferred)
PDBe Complex ID:
PDB-CPX-159071 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Actin, cytoplasmic 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 375 amino acids
Theoretical weight: 41.84 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P63261 (Residues: 1-375; Coverage: 100%)
Gene names: ACTG, ACTG1
Sequence domains: Actin
Myosin-binding protein C, cardiac-type Chains: G, H, I, J, K, L
Molecule details ›
Chains: G, H, I, J, K, L
Length: 109 amino acids
Theoretical weight: 12.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14896 (Residues: 151-258; Coverage: 9%)
Gene name: MYBPC3
Sequence domains: Immunoglobulin I-set domain
Tropomyosin Chains: M, N, O, P
Molecule details ›
Chains: M, N, O, P
Length: 135 amino acids
Theoretical weight: 11.51 KDa
Source organism: Sus scrofa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 9Å
Relevant EMDB volumes: EMD-4346
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

4 review citations

Role of intrinsic disorder in muscle sarcomeres.
Tolkatchev et al. (2019)
3 more

5 mentions without citation

N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament.
Risi et al. (2018)
4 more