› 6gb1

X-ray diffraction
2.73Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154992 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glucagon-like peptide 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43220 (Residues: 21-145; Coverage: 28%)
Gene name: GLP1R
Sequence domains: Hormone receptor domain
Peptide 11 Chain: B
Molecule details ›
Chain: B
Length: 32 amino acids
Theoretical weight: 3.24 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand HEZ 2 x HEZ
1 modified residue:
Ligand AIB 1 x AIB

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 55.55Å b: 55.55Å c: 138.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.262
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases.
Clemmensen et al. (2019)
1 more