› 6gf1

X-ray diffraction
1.92Å resolution

The structure of the ubiquitin-like modifier FAT10 reveals a novel targeting mechanism for degradation by the 26S proteasome

Released:
DOI: 10.2210/pdb6gf1/pdb
PDB entry 6gf1 coloured by chain, front view.
PDB entry 6gf1 coloured by chain, side view.
PDB entry 6gf1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation.
Aichem A, Anders S, Catone N, Rößler P, Stotz S, Berg A, Schwab R, Scheuermann S, Bialas J, Schütz-Stoffregen MC, Schmidtke G, Peter C, Groettrup M, Wiesner S
Nat Commun 9 3321 (2018)
PMID: 30127417

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127352 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin D Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 83 amino acids
Theoretical weight: 9.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15205 (Residues: 10-86; Coverage: 47%)
Gene names: FAT10, UBD
Sequence domains: Ubiquitin family

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R3
Unit cell:
a: 116.172Å b: 116.172Å c: 84.72Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.21 0.233
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Regulation of Interferon Induction by the Ubiquitin-Like Modifier FAT10.
Mah et al. (2020)
3 more

5 mentions without citation

Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications.
Vaughan et al. (2021)
4 more