› 6gfb

X-ray diffraction
2.08Å resolution

Structure of the BTB/POZ domain of human 90K

Released:
DOI: 10.2210/pdb6gfb/pdb
PDB entry 6gfb coloured by chain, front view.
PDB entry 6gfb coloured by chain, side view.
PDB entry 6gfb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K Is Species Specific.
Lodermeyer V, Ssebyatika G, Passos V, Ponnurangam A, Malassa A, Ewald E, Stürzel CM, Kirchhoff F, Rotger M, Falk CS, Telenti A, Krey T, Goffinet C
J Virol 92 (2018)
PMID: 29743357

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170641 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-3-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 166 amino acids
Theoretical weight: 18.09 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q08380 (Residues: 124-250; Coverage: 22%)
Gene names: LGALS3BP, M2BP

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P3121
Unit cell:
a: 70.34Å b: 70.34Å c: 105.51Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.208 0.243
Expression system: Drosophila melanogaster

Quick links

Citations

5 review citations

Algae-Derived Bioactive Molecules for the Potential Treatment of SARS-CoV-2.
Alam et al. (2021)
4 more

3 mentions without citation

Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma.
Chen et al. (2021)
2 more