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› 6gko

X-ray diffraction
1.84Å resolution

Mouse thymidylate synthase cocrystallized with dUMP and soaked in phenolphthalein

Released:
DOI: 10.2210/pdb6gko/pdb
Model geometry
Fit model/data
PDB entry 6gko coloured by chain, front view.
PDB entry 6gko coloured by chain, side view.
PDB entry 6gko coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Maj P, Wilk P, Jarmula A, Weiss MS, Rode W

Function and Biology Details

Reaction catalysed: 
dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate +dTMP.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139660 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidylate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 307 amino acids
Theoretical weight: 35 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P07607 (Residues: 1-307; Coverage: 100%)
Gene name: Tyms
Sequence domains: Thymidylate synthase

Ligands and Environments

3 bound ligands:
Ligand UMP 2 x UMP
Ligand FGT 2 x FGT
Ligand DMS 2 x DMS
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 160.701Å b: 87.441Å c: 68.515Å
α: 90° β: 96.02° γ: 90°
R-values:
R R work R free
0.194 0.193 0.221
Expression system: Escherichia coli

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