› 6gkt

X-ray diffraction
2.1Å resolution

X-ray structure of a non-autocrystallizing galectin-10 variant, Gal10-Tyr69Glu

Released:
DOI: 10.2210/pdb6gkt/pdb
Model geometry
Fit model/data
PDB entry 6gkt coloured by chain, front view.
PDB entry 6gkt coloured by chain, side view.
PDB entry 6gkt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Gonçalves A, Van Gorp H, De Haard H, Blanchetot C, Saunders M, Hammad H, Savvides SN, Lambrecht BN
Science 364 (2019)
PMID: 31123109

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170169 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-10 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 144 amino acids
Theoretical weight: 16.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q05315 (Residues: 1-142; Coverage: 100%)
Gene names: CLC, LGALS10, LGALS10A
Sequence domains: Galactoside-binding lectin

Ligands and Environments

3 bound ligands:
Ligand PGE 8 x PGE
Ligand PG4 1 x PG4
Ligand P6G 1 x P6G
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 72.823Å b: 93.296Å c: 93.068Å
α: 90° β: 108.94° γ: 90°
R-values:
R R work R free
0.174 0.172 0.204
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

43 review citations

Intersection of biology and therapeutics: type 2 targeted therapeutics for adult asthma.
Peters et al. (2020)
42 more

1 mention without citation

The Underling Mechanisms Exploration of Rubia cordifolia L. Extract Against Rheumatoid Arthritis by Integrating Network Pharmacology and Metabolomics.
Zeng et al. (2023)