› 6gme

X-ray diffraction
1.8Å resolution

Structure of H. sapiens SPT6 tandem SH2 domain

Released:
DOI: 10.2210/pdb6gme/pdb
PDB entry 6gme coloured by chain, front view.
PDB entry 6gme coloured by chain, side view.
PDB entry 6gme coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.
Vos SM, Farnung L, Boehning M, Wigge C, Linden A, Urlaub H, Cramer P
Nature 560 607-612 (2018)
PMID: 30135578

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181613 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription elongation factor SPT6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 201 amino acids
Theoretical weight: 22.9 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q7KZ85 (Residues: 1338-1520; Coverage: 11%)
Gene names: KIAA0162, SPT6H, SUPT6H
Sequence domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 51.02Å b: 81.1Å c: 51.37Å
α: 90° β: 115.08° γ: 90°
R-values:
R R work R free
0.192 0.191 0.223
Expression system: Trichoplusia ni

Quick links

Citations

46 review citations

Gene regulation by long non-coding RNAs and its biological functions.
Statello et al. (2021)
45 more

1 mention without citation

What's all the phos about? Insights into the phosphorylation state of the RNA polymerase II C-terminal domain via mass spectrometry.
LeBlanc et al. (2021)